Excessive consumption of the sugar rich longan fruit promoted the development of nonalcoholic fatty liver disease via mediating gut dysbiosis

Controversy exists as toward the association of excessive fruits intake and certain disease risks. Longan is an edible fruit rich in high levels fructose, glucose sucrose. Herein, effect longan on development nonalcoholic fatty liver (NAFLD) was investigated. extracts at doses 4.0 g/kg, 8.0, 16.0 g/kg were orally administered for 4 weeks to healthy C57BL/6J mice or fed with a HFD diet. In normal diet, repeated excess (8 16 g/kg), but not dose (4 promoted inflammation gut dysbiosis-like status reduced short-chain acids (SCFAs) production. high-fat diet (HFD)-fed mice, hardly influenced NAFLD development. contrast, g/kg) pathogenesis, including increased abnormality hepatic indices, elevated inflammation, permeability associated more severe steatosis fibrosis. Moreover, exacerbated pathogenic markers positively correlated blood sugar, aggravated HFD-associated microbial dysbiosis. Effects mediated by resembled that equivalent free sugars supplementation, suggesting level contributed promotion demonstrated case intake.